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In addition to High-dose intravenous acetylcholine severe vasodilation and a profound drop in blood pressure, the high concentration of acetylcholine directly stimulates M2 muscarinic receptors in the sinoatrial (SA) node of the heart (Brown & Eccles, 1934)

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Additionally, the convenience of pre-filled cartridges or easy-to-refill designs means that users don't have to deal with the mess or preparation associated with other forms of cannabis consumption, such as rolling joints or packing bowls